Micronuclei accumulation

1. SIRT6 decreases micronuclei accumulation in cells.

   “SIRT6 loss led to nuclear envelope breakdown and micronuclei accumulation, resembling accelerated-aging phenotypes.”

   CellsShown by SIRT6 depletionneuron-like cells

   Aging in Fast-Forward: An Inducible SIRT6 Deficiency model as a Lens on Brain Aging and Neurodegeneration

   bioRxiv (Cold Spring Harbor Laboratory)·17 Feb 2026Preprint

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