There are 4 papers on MHC-II expression in aging research: 2 observational studies in people, 2 in animals.
4 papers study it4 more mention it3 findings
See all 8 papers on MHC-II expression
- Humans2
- Animals2
Interventions
240-hz light flicker
upin mice1
1 study
40-hz light flicker
upin mice1
40-hz light flicker increases MHC-II expression in mice.
“The 40-Hz light flicker upregulated MHC-II expression in the retinas of aged mice.”
Animalsretina40 Hz
Retinal Amyloid Clearance Enhanced by 40-Hz Light Flicker via MHC-II+ Microglia Regulation in Mice
Investigative ophthalmology & visual science
Extracellular vesicles
upin human cells1
1 study
Extracellular vesicles
upin human cells1
Extracellular vesicles increase MHC-II expression in human cells (comparison of extracellular vesicles from older and younger individuals).
“EVs from older individuals were more readily internalized by B cells and increased MHC-II expression on monocytes compared with EVs from younger individuals”
Cellscomparison of extracellular vesicles from older and younger individualsplasma extracellular vesiclesmonocyte
Scientific reports
Upstream
1IL-6
upin mice1
1 study
IL-6
upin mice1
IL-6 increases MHC-II expression in mice (shown by IL-6 knockout compared with wild-type mice).
“showed significantly less MHC-II expression in aged IL-6-/- compared to IL-6+/+ counterparts.”
Animalsshown by IL-6 knockout compared with wild-type micemicroglia
Microglia priming by interleukin-6 signaling is enhanced in aged mice
Journal of neuroimmunology