Metabolomic risk scores

1. Metabolomic risk scores mediate cardiovascular disease in humans (indirect proportion 34.1%; 20.8% adjusted).

   Humansrheumatoid arthritis risk factor control associationn = 4,426

   Comprehensive Risk Factor Control Attenuates Excess Cardiovascular Risk in Rheumatoid Arthritis: A Prospective Cohort Study · European journal of preventive cardiology · 5 Sep 2026

Cardiovascular disease →

1. Metabolomic risk scores are associated with type 2 diabetes in humans.

   Humans10-year increases in plasma metabolites

   Blood Metabolomic Signatures of 1-Hour Glucose Predict Cardiometabolic Risk · Circulation research · 1 Sep 2026

2. Metabolomic risk scores raise the risk of type 2 diabetes in humans (RR 3.80, 95% CI 2.22-6.51).

   Humanstop 20% vs lowest 20% MRSfemales

   Blood Metabolomic Signatures of 1-Hour Glucose Predict Cardiometabolic Risk · Circulation research · 1 Sep 2026

Type 2 diabetes →

1. Metabolomic risk scores raise the risk of coronary heart disease in humans (RR 1.48, 95% CI 1.04-2.12).

   Humanstop 20% vs lowest 20% MRSfemales

   Blood Metabolomic Signatures of 1-Hour Glucose Predict Cardiometabolic Risk · Circulation research · 1 Sep 2026

Coronary heart disease →

1. Metabolomic risk scores are associated with bone mineral density in humans.

   Humansafter adjustment for age and BMIplasmafemalesn = 200

   Metabolomics of Osteoporosis: The Vietnam Osteoporosis Study · Research Square · 24 Aug 2026 · Preprint

1. Metabolomic risk scores predict osteoporosis in humans (AUC 0.93 (95% CI: 0.90–0.97)).

   Humansafter adjustment for age and BMIplasmafemalesn = 200

   Metabolomics of Osteoporosis: The Vietnam Osteoporosis Study · Research Square · 24 Aug 2026 · Preprint

Osteoporosis →