Metabolic, immune, and stress-response gene expression

1. Reserpine decreases metabolic, immune, and stress-response gene expression in flies.

   “reserpine induces a transcriptionally repressed, low-energy state characterized by downregulation of metabolic, immune, and stress-response genes in treated aged animals.”

   Model organisms

   Reserpine prolongs lifespan but compromises heat-stress resilience in Drosophila melanogaster

   bioRxiv (Cold Spring Harbor Laboratory)·24 Aug 2025Preprint

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