Hippocampus volume

1. Hippocampus volume mediates neuropsychiatric symptoms in humans (mediating proportions ranging from 8.40% to 9.29%).

   “the influence of frailty on NPSs was partially mediated by hippocampus volume, whole brain volume, and monocytes, with mediating proportions ranging from 8.40% to 9.29%.”

   Humansmild cognitive impairment

   Associations of frailty with neuropsychiatric symptoms of Alzheimer's Disease: a longitudinal study

   AAIC 2025 abstract·23 Dec 2025

1. Hippocampus volume is associated with memory performance in humans (p < .01).

   “Associations with CSF pTau ( p < .001) and hippocampus volume ( p < .01) were observed when examining longitudinal change in memory over time.”

   Humanscognitively unimpairedmean follow‐up: 7.08 ± 1.14 years57% femalesn = 79

   Multimodal predictors of cross‐sectional and longitudinal memory in a cognitively unimpaired aging cohort

   AAIC 2025 abstract·8 Jan 2026

1. Plasma NfL is associated with hippocampus volume in humans (r = -0.39, p < 0.0001).

   “hippocampus volume (Pearson r = ‐0.39, p < 0.0001)”

   Humanscognitively healthy older subjectsplasman = 77

   Ageing and Neurodegeneration: A Study of Plasma Biomarkers and Neuroimage in a Brazilian Cohort

   AAIC 2025 abstract·25 Dec 2025

More on Plasma NfL

1. DTI-ALPS index is associated with hippocampus volume in humans.

   “The DTI‐ALPS index exhibited positive correlations with volumes in the basal forebrain, entorhinal cortex, and hippocampus”

   Humanscognitively unimpaired

   Glymphatic system function associates with AD‐signature region volumes, plasma biomarkers, and white matter hyperintensity progression in cognitively unimpaired elderly

   AAIC 2025 abstract·24 Dec 2025

More on DTI-ALPS index