1 paper2 findings
Memory composite score
downin humans1
LC MRI intensity is associated with memory composite score in humans (P = .01).
“lower LC intensity was associated with worse memory at low (P = .01), but not high (P = .64) pTau217 levels.”
Humansat low pTau217 levels, adjusted for educationlocus coeruleusn = 127
Brainstem MRI signal links to an Alzheimer's marker in adults
medRxiv9 Oct 2026Preprint
p-Tau217
upin humans1
LC MRI intensity is associated with p-Tau217 in humans (B = 0.17, P = .02).
“After adjustment for age, sex, and APOE4 carrier status, lower LC intensity was associated with higher plasma pTau217 concentrations (B = 0.17, P = .02).”
Humansadjusted for age, sex, and APOE4 carrier statuslocus coeruleusn = 163
Brainstem MRI signal links to an Alzheimer's marker in adults
medRxiv9 Oct 2026Preprint
Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.Each standard deviation decrease in locus coeruleus intensity was associated with 53% higher odds of testing positive for an Alzheimer's blood marker.