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Matriglycan

Biomarker

2 papers2 findings

  • Animals2

Interventions

2

Ribitol

upin mice1

1 study

  1. Ribitol increases matriglycan in mice.

    “This was associated with a dose dependent increase in matriglycan”

    Animalsin FKRP-P448L mutant mice6 months

    Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model

    PloS one1 Dec 2022

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Aav2/9 cmv LARGE1

upin mice1

1 study

  1. Aav2/9 cmv LARGE1 increases matriglycan in mice.

    “restores matriglycan expression on dystroglycan”

    Animalsin older myd mice with severe muscular dystrophy

    Large1 gene transfer in older myd mice with severe muscular dystrophy restores muscle function and greatly improves survival

    Science advances25 May 2022

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