ANTI-IL-21R monoclonal antibody
Intervention1 paper4 findings
- Animals1
Outcomes
4Inflammation
downin mice1Very low certainty
1 study
Inflammation
downin mice1Very low certainty
ANTI-IL-21R monoclonal antibody decreases inflammation in mice.
Animalsaged Ldlr-/- mice with well-established plaquesfemales
IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice · Atherosclerosis · 3 Sep 2026
Treg frequencies
upin mice1Very low certainty
1 study
Treg frequencies
upin mice1Very low certainty
ANTI-IL-21R monoclonal antibody increases Treg frequencies in mice.
Animalsyoung Ldlr-/- mice
IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice · Atherosclerosis · 3 Sep 2026
Macrophage content
downin mice1Very low certainty
1 study
Macrophage content
downin mice1Very low certainty
ANTI-IL-21R monoclonal antibody decreases macrophage content in mice (-61% (p = 0.053)).
Animalsyoung Ldlr-/- mice
IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice · Atherosclerosis · 3 Sep 2026
Atherosclerotic plaque area
downin mice1Very low certainty
1 study
Atherosclerotic plaque area
downin mice1Very low certainty
ANTI-IL-21R monoclonal antibody decreases atherosclerotic plaque area in mice (-38% (p < 0.05)).
Animalsyoung Ldlr-/- mice
IL-21R blockade reduces inflammation and atherosclerosis in LDL receptor deficient mice · Atherosclerosis · 3 Sep 2026