Lymphocyte clonality

1. POT1 increases lymphocyte clonality in humans (12 of 20 (60%)).

   “Among asymptomatic POT1 variant carriers, 12 of 20 (60%) had immunophenotype-detected B- and/or T-cell clonality, with complete penetrance after the age of 65 years (7/7).”

   Humansamong asymptomatic POT1 variant carriersn = 20

   Lymphoid malignancy and clonality in the POT1-mediated long telomere syndrome

   Blood·21 Jan 2026

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