LE8 score

Biomarker

2 papers

  • Humans2

Latest

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JACC CardioOncology

Heart health linked to lower coronary risk in mutation carriers

A standard-deviation score increase was linked to coronary disease hazard ratios (relative event rates) of 0.74 in mutation carriers versus 0.68 in noncarriers.A standard-deviation score increase was linked to coronary disease hazard ratios (relative event rates) of 0.74 in mutation carriers versus 0.68 in noncarriers.

Cohort study of 427,295 UK Biobank participants, median 13.6-year follow-upPopulations

Limit: Coronary risk reduction from actively improving cardiovascular health scores was not measured

Clinical Journal of the American Society of Nephrology

Lower heart-health scores linked to end-stage kidney disease

Each 10-point lower heart-health score was linked to a hazard ratio—a measure of relative risk over time—of 1.47 for end-stage kidney disease.Each 10-point lower heart-health score was linked to a hazard ratio—a measure of relative risk over time—of 1.47 for end-stage kidney disease.

Cohort study of 276,494 UK Biobank participants without end-stage kidney disease, median 14.1 yearsEnd-stage kidney disease

Limit: The study measured risk associated with scores, not kidney benefits from improving them

medRxiv

Brain small-vessel disease differed by ethnic and racial group

Black participants’ odds of greater combined disease burden were 1.66 times those of South Asian participants and 2.36 times those of Chinese participants.Black participants’ odds of greater combined disease burden were 1.66 times those of South Asian participants and 2.36 times those of Chinese participants.

Preprint: cross-sectional study of 1,377 UK Biobank imaging participants, against South Asian participantsPopulations

Limit: Healthcare access and discrimination were incompletely captured, potentially confounding ethnic-group comparisons

Clinical Epigenetics

Biological aging and heart health link to lung disease risk

A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.A study of 181,955 UK Biobank participants linked accelerated biological aging and lower cardiovascular health to higher risks of chronic respiratory diseases.

Study in peoplePopulations