L5

1. L5 is associated with GrimAge in humans (β 0.60 (95% CI 0.06–1.13)).

   “Higher L5 activity and IV were associated with higher GrimAge acceleration (L5: β, 0.60 [95% CI, 0.06-1.13]; P = .03;”

   Humansfully adjusted modelblood7-day actigraphyn = 207

   Twenty-Four-Hour Rest-Activity Rhythms and Epigenetic Age Acceleration in Middle-Aged and Older Adults

   JAMA network open·1 May 2026

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