What does the research say about Kidney volume?

Kidney volume

There are 5 papers on kidney volume in aging research: 2 trials and 3 observational studies in people. The newest story, Oct 21, 2026: “Kidney layers showed contrasting disease links in adults”.

Biomarker

5 papers study it23 more mention it1 finding

3 new papers in 30 daysSee all 28

Human trial2
Humans3

Interventions

Bariatric surgery

downin humans1

1 study

Bariatric surgery decreases kidney volume in humans (severe obesity) (-35.1 ± 25.2 cm3, -11 %).
“Significant reductions were observed in body weight (-31.1 ± 8.7 kg, -27 %), RMR (-356 ± 237 kcal/day, -17 %), kidney volume (-35.1 ± 25.2 cm3, -11 %), and liver volume (-384 ± 250 cm3, -21 %) (p < 0.01 for all)”
Human trialsevere obesity26 weeksn = 47
Liver and Kidney volume Reduction May Underlie Metabolic Adaptation After Metabolic Bariatric Surgery: A sub-study of the "POWER" Randomized clinical trial
Clinical nutrition (Edinburgh, Scotland)Mar 11, 2026

Latest

13 papers in 12 months

medRxivOct 21

Kidney layers showed contrasting disease links in adults

Chronic kidney disease was linked to thinning across 87.7% of the left kidney’s inner region and 72.8% of the right.Chronic kidney disease was linked to thinning across 87.7% of the left kidney’s inner region and 72.8% of the right.

Preprint: cohort · 70,270 peopleBiomarkers

Paper

Clinical NutritionMar 25

Liver and Kidney volume Reduction May Underlie Metabolic Adaptation After Metabolic Bariatric Surgery: A sub-study of the "POWER" Randomized clinical trial

Randomized trial in 47 peopleBariatric surgery

Paper

Communications MedicineMar 12

Multilevel metabolic adaptation to exercise training

Non-randomized trial in 16 peopleExercise

Paper

Scientific ReportsMar 10

Precision MRI phenotyping enables detection of small changes in body composition for longitudinal cohorts

Cohort study of 3,088 peopleBiomarkers

Paper

Nephrology, Dialysis, TransplantationSep 1

Kidney size in relation to ageing, gender, renal function, birthweight and chronic kidney disease risk factors in a general population

Cross-sectional study of 3,972 peopleBiomarkers

Paper

Journal of the American Society of NephrologyOct 25

Empagliflozin was well tolerated in a kidney disease trial

In both groups, 96% tolerated the full dose; height-adjusted kidney volume grew 10.5% a year with empagliflozin versus 5.1% with placebo.In both groups, 96% tolerated the full dose; height-adjusted kidney volume grew 10.5% a year with empagliflozin versus 5.1% with placebo.

Randomized trial · 50 peopleEmpagliflozin

Paper

American Journal of NephrologyOct 18

Daily Caloric Restriction in Overweight and Obese Adults with ADPKD: Rationale and Protocol of a Randomized Controlled Trial

Study protocolDietary restriction

Paper

European Journal of RadiologySep 30

Human abdominal organ volumes peak in midlife then decline

In 15,408 adult patients, automated CT analysis showed liver, pancreas, and kidney volumes peaked in midlife before declining, while tissue attenuation generally dropped…In 15,408 adult patients, automated CT analysis showed liver, pancreas, and kidney volumes peaked in midlife before declining, while tissue attenuation generally dropped with age.

Cross-sectional study of 15,408 peoplePopulations

Paper

NMR in BiomedicineSep 11

MRI scans estimated kidney function in healthy adults

About 87%–92% of MRI-based estimates fell within 30% of blood-test-based estimates in statistical testing and prospective validation.About 87%–92% of MRI-based estimates fell within 30% of blood-test-based estimates in statistical testing and prospective validation.

Cross-sectional · 20 peopleBiomarkers

Paper

LifeAug 27

Age, Sex, and Laterality-Based Evaluation of Renal Volume and Surface Area Using CT-Based Three-Dimensional Segmentation

Cross-sectional study of 291 peopleKidney

Paper

See all 28

Kidney volume

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