What does the research say about Irisin change?

Irisin change

There is 1 paper on irisin change in aging research: 1 trial in people. The newest story, Nov 1, 2026: “Spice extract reduced body fat in Korean adults with overweight”.

Biomarker

1 paper studies it1 more mentions it2 findings

1 new paper in 30 daysSee all 2

“PBMC MuRF1 mRNA, an exploratory biomarker, correlated inversely with serum irisin change in the pooled population (r = -0.61; p = 0.0003).”

Pure 6-paradol activates the TRPV1-PGC-1α-FNDC5-irisin axis in cultured myotubes, and a 6-paradol-standardised Aframomum melegueta K. Schum. extract reduces adiposity with relative preservation of lean mass in Korean adults with overweight: an integrated mechanistic and randomised controlled trial investigationThe Journal of nutritional biochemistry2026doi:10.1016/j.jnutbio.2026.110530

Human trial1

Associations

TRIM63

downin humans1

1 study

TRIM63 is associated with irisin change in humans (exploratory analysis in the pooled trial population) (r = -0.61; p = 0.0003).
“PBMC MuRF1 mRNA, an exploratory biomarker, correlated inversely with serum irisin change in the pooled population (r = -0.61; p = 0.0003).”
Human trialexploratory analysis in the pooled trial populationPBMC and serum12 weeks
Spice extract reduced body fat in Korean adults with overweight
The Journal of nutritional biochemistryOct 31, 2026

Latest

2 papers in 12 months

The Journal of Nutritional BiochemistryNov 1

Spice extract reduced body fat in Korean adults with overweight

Body fat fell by 4.2 percentage points with the extract versus 0.8 with placebo in a 12-week randomized trial.Body fat fell by 4.2 percentage points with the extract versus 0.8 with placebo in a 12-week randomized trial.

Randomized trial · 65 peopleOverweight

Paper

International Journal of Molecular SciencesFeb 27

Environmental Enrichment Attenuates Aging-Induced BBB Disruption and Cognitive Impairment with Activation of FNDC5/Irisin Signaling

Experiments in miceCognitive impairment