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Aframomum melegueta

Aframomum melegueta has been studied in 1 paper since 2026: 1 trial in people; 1 in the past year. The newest story, Nov 1, 2026: “Spice extract reduced body fat in Korean adults with overweight”.

Intervention

1 paper studies it3 findingsUpdated

1 new paper in 30 daysSee all 1

“body fat percentage changed -4.2 vs. -0.8 percentage points (adjusted between-group difference -3.4 percentage points; 95% CI -4.5 to -2.3; d = 1.14)”
Pure 6-paradol activates the TRPV1-PGC-1α-FNDC5-irisin axis in cultured myotubes, and a 6-paradol-standardised Aframomum melegueta K. Schum. extract reduces adiposity with relative preservation of lean mass in Korean adults with overweight: an integrated mechanistic and randomised controlled trial investigationThe Journal of nutritional biochemistry2026doi:10.1016/j.jnutbio.2026.110530

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Funder: National Research Foundation of Korea
  • Human trial1

Studies in people

1 study gave aframomum melegueta to people and measured what changed.

  • down: Decreases body fat percentage-3.4 percentage points versus placebo; 95% CI -4.5 to -2.3; d = 1.14

    up: Increases lean body mass-0.3 versus -1.1 kg; between-group difference +0.8 kg; 95% CI +0.03 to +1.57

    up: Increases irisin+40.1 ng/mL versus placebo; 95% CI +30.2 to +50.0; d = 1.67

    Randomized trial65 people20–50 years12 weeks

    General population; Midlife adults; healthy Korean adults with overweight; BMI 25–30 kg/m2

    The Journal of nutritional biochemistry, Oct 31, 2026

What did studies of Aframomum melegueta find?

3

Studies of Aframomum melegueta measured 3 outcomes; the most studied are irisin (1 study), lean body mass (1) and body fat percentage (1).

Irisin

upin humans1

1 study

  1. Aframomum melegueta increases irisin in humans (healthy Korean adults with overweight; compared with placebo) (+40.1 ng/mL versus placebo; 95% CI +30.2 to +50.0; d = 1.67).

    “serum irisin rose +42.6 vs. +2.5 ng/mL (+40.1 ng/mL; 95% CI +30.2 to +50.0; d = 1.67)”

    Human trialhealthy Korean adults with overweight; compared with placebo6-paradol-standardized extractserum500 mg/day12 weeksn = 65

    Spice extract reduced body fat in Korean adults with overweight

    The Journal of nutritional biochemistry

More on Irisin

Lean body mass

upin humans1

1 study

  1. Aframomum melegueta increases lean body mass in humans (-0.3 versus -1.1 kg; between-group difference +0.8 kg; 95% CI +0.03 to +1.57).

    “lean mass showed relative preservation (-0.3 vs. -1.1 kg; +0.8 kg; 95% CI +0.03 to +1.57; d = 0.82)”

    Human trialhealthy Korean adults with overweight; BMI 25–30 kg/m2; relative preservation compared with placebo6-paradol-standardized extract500 mg/day12 weeksn = 65

    Spice extract reduced body fat in Korean adults with overweight

    The Journal of nutritional biochemistry

Body fat percentage

downin humans1

1 study

  1. Aframomum melegueta decreases body fat percentage in humans (healthy Korean adults with overweight; BMI 25–30 kg/m2; compared with placebo) (-3.4 percentage points versus placebo; 95% CI -4.5 to -2.3; d = 1.14).

    “body fat percentage changed -4.2 vs. -0.8 percentage points (adjusted between-group difference -3.4 percentage points; 95% CI -4.5 to -2.3; d = 1.14)”

    Human trialhealthy Korean adults with overweight; BMI 25–30 kg/m2; compared with placebo6-paradol-standardized extract500 mg/day12 weeksn = 65

    Spice extract reduced body fat in Korean adults with overweight

    The Journal of nutritional biochemistry

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 1Nov 2026: 01 paper in 12 months
The Journal of Nutritional Biochemistry

Spice extract reduced body fat in Korean adults with overweight

Body fat fell by 4.2 percentage points with the extract versus 0.8 with placebo in a 12-week randomized trial.Body fat fell by 4.2 percentage points with the extract versus 0.8 with placebo in a 12-week randomized trial.

Randomized trial · 65 peopleOverweight
Paper

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