IntrinClock
2 papers4 findings
- Humans2
Interventions
2Fasting
no changein humans1
1 study
Fasting
no changein humans1
Fasting has no effect on IntrinClock in humans (immune R 2 = 3.2%).
“IntrinClock, designed to exclude immune-variable CpGs, showed no fasting effect in either cohort (immune R 2 = 3.2%), serving as a negative control.”
Human trialpaired fasting designn = 15
Fasting Status and Epigenetic Clock Stability: Implications for Aging Research
bioRxiv (Cold Spring Harbor Laboratory)7 Jun 2026Preprint
Oskm-mediated reprogramming
downin human cells1
1 study
Oskm-mediated reprogramming
downin human cells1
Oskm-mediated reprogramming decreases IntrinClock in human cells.
“IntrinClock showed a robust predicted epigenetic age increase in a model of replicative senescence in vitro and age reversal during OSKM-mediated reprogramming.”
Cells
Development of a novel epigenetic clock resistant to changes in immune cell composition
bioRxiv (Cold Spring Harbor Laboratory)2 Mar 2023Preprint
Upstream
1Immune cell type
no changein human cells1
1 study
Immune cell type
no changein human cells1
immune cell type has no effect on IntrinClock in human cells.
“the IntrinClock, that did not change among 10 immune cell types tested.”
Cellscomparison among 10 immune cell typesimmune cell
Development of a novel epigenetic clock resistant to changes in immune cell composition
bioRxiv (Cold Spring Harbor Laboratory)2 Mar 2023Preprint
Associations
1Cellular senescence
upin human cells1
1 study
Cellular senescence
upin human cells1
Cellular senescence is associated with IntrinClock in human cells.
“IntrinClock showed a robust predicted epigenetic age increase in a model of replicative senescence in vitro”
Cellsin vitro model of replicative senescence
Development of a novel epigenetic clock resistant to changes in immune cell composition
bioRxiv (Cold Spring Harbor Laboratory)2 Mar 2023Preprint