In 5,774 adults followed for an average of 4.7 years, carrying two APOE ε4 alleles and female sex were linked to faster hippocampal shrinkage.In 5,774 adults followed for an average of 4.7 years, carrying two APOE ε4 alleles and female sex were linked to faster hippocampal shrinkage.
In 198 adults aged 40 to 65, larger brainstem volume tied to better memory, with the strongest link seen in participants with elevated arterial stiffness.In 198 adults aged 40 to 65, larger brainstem volume tied to better memory, with the strongest link seen in participants with elevated arterial stiffness.
In 510 older adults, higher performance variability tracked lower anisotropy in specific tracts, with an effect size of 0.09 across 7.57% of whole-brain tract volume.In 510 older adults, higher performance variability tracked lower anisotropy in specific tracts, with an effect size of 0.09 across 7.57% of whole-brain tract volume.
In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical area in men.In 104 older adults followed for nine years, white matter aberrations grew 7.2% annually, tracking greater cortical thinning and expanded cortical area in men.
In 120 older adults, cerebrovascular reactivity and gray matter volume interacted in parietal and occipital lobes to influence executive function.In 120 older adults, cerebrovascular reactivity and gray matter volume interacted in parietal and occipital lobes to influence executive function.