Integrated systemic biomarker-burden score

1. Melatonergic-axis score is associated with integrated systemic biomarker-burden score in humans (ρ = -0.944).

   “The melatonergic-axis score correlated inversely with integrated systemic burden (Spearman ρ = -0.944; 5000-resample bootstrap 95% CI, -0.953 to -0.931; p < 0.001).”

   Humansn = 314

   Relative Melatonergic Status and Systemic Inflammatory, Oxidative, and Biological Aging Burden in Adults: An Exploratory Cross-Sectional Biomarker Analysis

   Cancers·12 Aug 2026

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