IL-1β and IL-6

1. SARS-COV-2 infection is linked with IL-1β and IL-6 in severe COVID-19 patients.

   “exhibited increased senescence (p16INK4A and SenTraGor positivity) and interleukin (IL)-1β and IL-6 expression”

   Humansin severe COVID-19 patientsalveolar type 2 cells

   Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral mutagenesis

   The European respiratory journal·Jan 29, 2022

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1. Social subordination increases IL-1β and IL-6 in mice.

   “a significant increase in the levels of circulating pro-inflammatory cytokines IL-1β and IL-6”

   Animals

   Innate sensitivity to stress facilitates inflammation, alters metabolism and shortens lifespan in a mouse model of social hierarchy

   Aging·Nov 9, 2019

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1. Aged mice increases IL-1β and IL-6 in mice.

   “the levels of the inflammatory factors IL-1β and IL-6 were significantly increased”

   Animals

   TREM2 and CD163 Ameliorate Microglia-Mediated Inflammatory Environment in the Aging Brain

   Journal of molecular neuroscience : MN·Mar 19, 2022

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1. DNMT3A, TET2, ASXL1 mutations are associated with IL-1β and IL-6 in humans.

   “DTA mutations correlate with elevated proinflammatory cytokines such as IL-1β and IL-6”

   Review

   Clonal Hematopoiesis of Indeterminate Potential (CHIP): A Model of Mutation-Driven Thromboinflammation

   Cancers·Apr 22, 2026