SARS-COV-2 infection
Intervention2 papers4 findings
- Humans2
Outcomes
2IMMune Age indeX
downin humans1upin humans1Very low certainty
1 study
IMMune Age indeX
downin humans1upin humans1Very low certainty
SARS-COV-2 infection decreases IMMune Age indeX in humans.
Humans4 weeks after infection (t3) after clinical recoveryn = 9
Acute viral respiratory infections are not associated with an increased IMMune Age indeX (IMMAX) four weeks after infection: a prospective observational cohort study · Immunity & ageing : I & A · 22 Sep 2026
SARS-COV-2 infection increases IMMune Age indeX in humans.
Humansacute phase (t1)n = 9
Acute viral respiratory infections are not associated with an increased IMMune Age indeX (IMMAX) four weeks after infection: a prospective observational cohort study · Immunity & ageing : I & A · 22 Sep 2026
Functional capacity
no changein humans1Low certainty
1 study
Functional capacity
no changein humans1Low certainty
SARS-COV-2 infection has no effect on functional capacity in humans.
Humans18-month longitudinal follow-up post-pandemic18 monthsn = 1,072
Evolution of functional and mental status and quality of life in people aged 75 years and over after the COVID-19 pandemic in Spain: a prospective cohort study · BMC geriatrics · 7 Aug 2026
Associations
1Anxiety
mixedin humans1Low certainty
1 study
Anxiety
mixedin humans1Low certainty
SARS-COV-2 infection is associated with anxiety in humans (p = 0.043).
Humansdifferential longitudinal pattern over 18 months18 monthsn = 1,072
Evolution of functional and mental status and quality of life in people aged 75 years and over after the COVID-19 pandemic in Spain: a prospective cohort study · BMC geriatrics · 7 Aug 2026
Funding
National Institute on AgingUS$9.5mNational Institute of Neurological Disorders and StrokeUS$801.3k7 grants since 2022
National Institute on AgingUniversity of Texas Hlth Science CenterUS$1.8m2023–2028
National Institute on AgingUniversity of RochesterUS$724.4k2022–2027
National Institute on AgingHarvard University D/b/a Harvard School of Public HealthUS$88.2k2023–2029
National Institute on AgingUniversity of MinnesotaUS$700.1k2022–2027
National Institute on AgingCleveland Clinic Lerner Com-cwruUS$780.7k2023–2028
Alzheimer’s Disease Related Biomarkers following SARS-CoV-2 Infection
National Institute on AgingNew York University School of MedicineUS$1.4m2022–2027
National Institute of Neurological Disorders and StrokeUniversity of Illinois at ChicagoUS$801.3k2024–2029