Hippocampal ALFF

1. Hippocampal ALFF improves diagnostic discrimination in humans.

   “ROC analyses revealed that adding hippocampal ALFF to a basic A/T/N biomarker model improved diagnostic discrimination”

   Humansin A/T/N biomarker model

   Investigating hippocampal hyperexcitability as a biomarker of Alzheimer’s disease

   AAIC 2025 abstract·23 Dec 2025

1. Hippocampal ALFF is associated with medial temporal lobe tau-PET SUVR in humans.

   “Higher hippocampal ALFF significantly correlated with increased MTL tau in Aβ+ individuals”

   Humansin Aβ+ individualsmedial temporal lobe

   Investigating hippocampal hyperexcitability as a biomarker of Alzheimer’s disease

   AAIC 2025 abstract·23 Dec 2025

More on Medial temporal lobe tau-PET SUVR

1. Mild cognitive impairment is associated with hippocampal ALFF in humans.

   “Hippocampal and retrosplenial ALFF were elevated in individuals with MCI compared to CN individuals”

   Humanscomparing MCI to CN

   Investigating hippocampal hyperexcitability as a biomarker of Alzheimer’s disease

   AAIC 2025 abstract·23 Dec 2025

More on Mild cognitive impairment