Investigating hippocampal hyperexcitability as a biomarker of Alzheimer’s disease

Abstract

Background: Hippocampal hyperexcitability is an early feature of Alzheimer’s disease (AD) that may drive pathology. However, current models of AD risk focusing on the A/T/N framework (Aβ /Tau/Neurodegeneration) do not include hyperexcitability as a key disease biomarker.