1 paper
European Research Council€5.2mEuropean Commission€203.5k
Harnessing Hematopoietic Stem Cell Breakthroughs to Pioneer Advances in Transplantation Therapies
European Research CouncilUniversita Vita-Salute San Raffaele€1.5m2026–2030
The impact of human aged bone marrow niche on human hematopoietic stem cell function
European Research CouncilUniversitaet Ulm€1.5m2025–2029
European Research CouncilHelsingin Yliopisto€2.2m2025–2029
A bone marrow mimicry bioreactor for cost effective production of hematopoietic stem cells
European CommissionTechnische Universiteit Eindhoven€203.5k2025–2027
Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.Activating reprogramming factors for 16 days in old mice reduced DNA damage, improved blood reconstitution, and dampened transposable element activity.
In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.In cohort data and cell models, ASXL1 mutations tracked with incident aortic stenosis and promoted valvular calcification that was reduced by IL-1 or IL-6 inhibition.
Researchers found that boosting Lin28b expression during ex vivo culture restores the transplantation and reconstitution capacity of aged mouse hematopoietic stem cells.Researchers found that boosting Lin28b expression during ex vivo culture restores the transplantation and reconstitution capacity of aged mouse hematopoietic stem cells.