Annals of Clinical and Translational Neurology
Blood test model may reduce Alzheimer’s brain-scan use
Among 630 participants with uncertain blood results, predicted brain-scan referrals fell from 35.9% with one marker to 24.3% with the two-stage model.Among 630 participants with uncertain blood results, predicted brain-scan referrals fell from 35.9% with one marker to 24.3% with the two-stage model.
Cross-sectional · 630 peopleAlzheimer's disease
Who was studied630 cognitively unimpaired participants with indeterminate p-Tau217 results
What changedAmong people with indeterminate blood results, modeled brain-scan referrals fell from 35.9% with p-Tau217 alone to 24.3% with GRAD
The catchRenal function, which affects blood biomarker concentrations, was not accounted for