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In 12-month-old Col4a2 mutant mice, cerebral pial arteries showed impaired myogenic tone driven by PKA-dependent remodeling of ryanodine receptor clusters.In 12-month-old Col4a2 mutant mice, cerebral pial arteries showed impaired myogenic tone driven by PKA-dependent remodeling of ryanodine receptor clusters.
Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.Human neurons from frontotemporal lobar degeneration patients showed ultra-low-frequency TARDBP variants that were less abundant in individuals who died at older ages.
In a randomized trial, epicardial adipose volume fell by 15.15 mL more with exercise than in controls over 12 months.In a randomized trial, epicardial adipose volume fell by 15.15 mL more with exercise than in controls over 12 months.
In a driving simulator, dual-demand trials slowed older drivers' braking to 776 ms versus 605 ms in younger adults, with error rates reaching 11.67% compared to 3.04%.In a driving simulator, dual-demand trials slowed older drivers' braking to 776 ms versus 605 ms in younger adults, with error rates reaching 11.67% compared to 3.04%.
In 253 breast cancer survivors, a 12-month exercise program failed to beat wellness calls on primary cognitive tests, despite selective gains in attention and memory.In 253 breast cancer survivors, a 12-month exercise program failed to beat wellness calls on primary cognitive tests, despite selective gains in attention and memory.
