Free radical leak

1. Methionine restriction decreases free radical leak in rats (by 62-71%).

   “40% MetR decreases mitochondrial ROS production and percent free radical leak (by 62-71%) at complex I during forward (but not during reverse) electron flow in both brain and kidney mitochondria”

   Animals40% methionine restrictionbrain and kidney7 weeksmales

   Forty percent methionine restriction decreases mitochondrial oxygen radical production and leak at complex I during forward electron flow and lowers oxidative damage to proteins and mitochondrial DNA in rat kidney and brain mitochondria

   Rejuvenation research·1 Dec 2009

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