Firmicutes to Bacteroidetes ratio

1. Caloric restriction decreases Firmicutes to Bacteroidetes ratio in mice.

   “The PF BPH/5 dams exhibited a markedly reduced Firmicutes-to-Bacteroidetes ratio and increased abundance of Bacteroides and Lactobacillus in fecal samples”

   Animalsobese BPH/5 micefecesfemales

   Monitored food intake in early pregnancy modulates the maternal microbiome in the obese BPH/5 mouse model of superimposed preeclampsia

   Physiological genomics·24 Jan 2026

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1. Mediterranean diet decreases Firmicutes to Bacteroidetes ratio in rats.

   “Additionally, the Firmicutes to Bacteroidetes ratio, associated with gut homeostasis, was lower in the MeDi rats relative to the WD rats at 3.5 and 15.5 months of diet.”

   Animals3.5 and 15.5 monthsmalesn = 16

   Duration‐dependent Effects of Diet on Cognition and Gut Microbial Composition in an Aging Rat Model

   AAIC 2025 abstract·23 Dec 2025

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