Extracellular lactate

1 paper studies it5 more mention it1 finding

Cells1

Interventions

1

Passage

upin human cells1

1 study

Passage increases extracellular lactate in human cells.
“Metabolic profiling by NMR showed increased levels of extracellular lactate, phosphocholine and glycine in cells at later passages.”
Cellslate passage cells (passage 17 vs passage 4)fibroblastsfrom passage 4 to passage 17
The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence
International journal of molecular sciencesMay 23, 2022

More on Passage

Latest

1 paper in 12 months

Nature AgingDec 3

Peritumoral colonic epithelial cell-derived GDF15 sustains colorectal cancer via regulation of glycolysis and histone lactylation

Experiments in miceGlycolysis

International Journal of Biological MacromoleculesAug 6

Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts

Experiments in miceSkin

International Journal of Molecular SciencesMay 29

The Long-Term Culture of Human Fibroblasts Reveals a Spectroscopic Signature of Senescence

Experiments in human cellsBiomarkers

Laboratory Investigation; a Journal of Technical Methods and PathologyApr 12

Nicotinamide riboside, an NAD⁺ precursor, attenuates inflammation and oxidative stress by activating sirtuin 1 in alcohol-stimulated macrophages

Experiments in cellsInterventions

AgingJan 23

Anti-senescence role of heterozygous fumarate hydratase gene knockout in rat lung fibroblasts in vitro

Experiments in cellsMechanisms

PLOS OneOct 25

Astrocytic β2 Adrenergic Receptor Gene Deletion Affects Memory in Aged Mice

Experiments in animalsMechanisms