PLOS Genetics
A nerve-signal receptor has opposite effects on worm survival
Experiments with two bacterial strains found that the receptor’s effects on early deaths depended on insulin receptor activity in the worms.Experiments with two bacterial strains found that the receptor’s effects on early deaths depended on insulin receptor activity in the worms.
Worm studyMechanisms
Who was studiedCaenorhabditis elegans worms, against worms with normal insulin receptor function
What changedNMUR-1 reduced early deaths with normal insulin receptor function but increased them with reduced function on OP50 bacteria
The catchGenetic and gene-activity results provide indirect evidence for the proposed receptor-signaling buffering mechanism