Papers on epigenetic clock

1,674 papers47 new in 30 days

Sunday, August 30

Research SquareAug 30

In-depth characterization of the DNA methylation aging landscape links epigenetic noise and genotype-specific epigenetic aging to inflammaging

Preprint: study in peopleDNA methylation

Paper

Nature CommunicationsAug 30

Associations between diet quality, epigenetic aging and epigenome in two population-based cohorts

Correlation across diet-quality scores in the Rhineland Study.

Cohort study in peoplePopulations

Paper

Saturday, August 29

Ageing Research ReviewsAug 29

Living beyond our evolutionary warranty: Why non-communicable diseases may be the inevitable costs of an extended lifespan

ReviewMechanisms

Paper

Frontiers in MedicineAug 29

From skin aging biomarkers to precision esthetic longevity: a translational diagnostic framework

The proposed framework integrates five complementary diagnostic layers: systemic biological context, skin- and tissue-specific molecular biology, functional tissue behavior, imaging-based and…

ReviewBiomarkers

Paper

bioRxivAug 29

MOSurvivor-Guided Joint CpG Selection and XGBoost Hyperparameter Optimization for Compact Epigenetic Age Prediction

Preprint: computational studyBiomarkers

Paper

Friday, August 28

The Journal of Nutrition, Health & AgingAug 28

Mediterranean diet linked to weaker smoking-related aging signals

A cross-sectional analysis of 928 police employees linked closer Mediterranean diet adherence to smaller smoking-associated differences in blood-based aging measures.A cross-sectional analysis of 928 police employees linked closer Mediterranean diet adherence to smaller smoking-associated differences in blood-based aging measures.

Figure from The Journal of Nutrition, Health & Aging

Cross-sectional · 928 peopleBiomarkers

Paper

The Journals of Gerontology, Series AAug 28

Biological age associates with longitudinal frailty-related functional decline: the Health and Retirement Study

Cohort study of 4,018 peopleBiomarkers

Paper

Frontiers in MicrobiologyAug 28

High-fructose diet-induced gut dysbiosis as a mechanistic driver of chronic inflammation and accelerated biological aging: a comprehensive review

High-fructose diet–induced perturbation of intestinal microecology and initiation of the gut–liver inflammatory axis.

ReviewMicrobiome composition

Paper

bioRxivAug 28

Epigenetic Clocks Reveal Age Acceleration and Shared Methylation Remodeling Across Cancers

A: Age distribution of all tumor and normal samples, B: Distribution of normal and tumor samples in 8 cohorts

Preprint: computational studyEpigenetic clock

Paper

Thursday, August 27

International Journal of Gynaecology and ObstetricsAug 27

The womb as the cradle of longevity: Perinatal origins of biological aging

ReviewPopulations

Paper

International Journal of Molecular SciencesAug 27

DNA Methylation as a Programmable Information Layer: From Molecular Marks to Disease State Engineering

DNA methylation as a programmable information layer across biological scales.

ReviewDNA methylation

Paper

GenesAug 27

Non-Human Primates as a Comprehensive Model for Studying Epigenetic Markers of Aging

An overview establishing non-human primates as the premier model system for aging research due to their unique relevance to human biology.

ReviewMechanisms

Paper

Nature CommunicationsAug 27

The OmniAge compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality

Graphical summary of the OmniAge R/Python package.

Computational studyBlood and immune system

Paper

Wednesday, August 26

MetabolitesAug 26

Visceral Obesity and Its Complications: The Role of Bioelectrical Impedance Analysis in Longevity Medicine

Mechanistic progression from visceral adiposity to age-related disease, highlighting cross-cutting mechanisms discussed critically throughout Section 3 and Section 4.

ReviewVisceral obesity

Paper

Tuesday, August 25

Research SquareAug 25

The reset of aging counters in the germline and early embryo: a systematic review of centriole, telomere, mitochondrial, and epigenetic clocks across seven developmental transitions

Preprint: meta-analysisTelomerase and telomere maintenance

Paper

medRxivAug 25

Neighborhood Exposome at Birth and Trajectories of Epigenetic Age Acceleration Across Childhood

Neighborhood exposure profiles constructed using Self-Organizing Maps.

Preprint: cohort study of 570 peoplePopulations

Paper

Saturday, August 22

Mechanisms of Ageing and DevelopmentAug 22

DNA-based model predicted death risk in postmenopausal women

An observational analysis in postmenopausal women aged 50–79 found prediction comparable to one existing biological-age clock and better than another.An observational analysis in postmenopausal women aged 50–79 found prediction comparable to one existing biological-age clock and better than another.

Figure from Mechanisms of Ageing and Development

Cohort studyBiomarkers

Paper

EBioMedicineAug 22

Aging-marker patterns linked to quality of life in epilepsy

Quality-of-life scores rose 18.8 points in adults whose estimated aging rate rose then fell, versus 4.7 points with the opposite pattern during dietary therapy.Quality-of-life scores rose 18.8 points in adults whose estimated aging rate rose then fell, versus 4.7 points with the opposite pattern during dietary therapy.

Baseline characteristics of cumulative epigenetic clocks.

Single-arm trialInterventions

Paper

GeroScienceAug 22

Integrating biological aging into clinical practice: a review and path forward for precision longevity medicine

ReviewBiomarkers

Paper

Nature MedicineAug 22

Responsiveness of epigenetic aging biomarkers to longevity interventions in humans

Current paradigms to study the responsiveness of DNAm biomarkers and their limitations.

Computational studyBiomarkers

Paper

Friday, August 21

Child DevelopmentAug 21

Peer victimization, school belonging, and epigenetic aging among children of Latino immigrants

Cohort study of 341 peoplePopulations

Paper

Thursday, August 20

iScienceAug 20

The applicability of DNA methylation-based tools in a low-income, sub-Saharan African population: Malawi longitudinal study of families and health

Cohort study of 49 peopleBiomarkers

Paper

medRxivAug 20

A Randomized Clinical Trial of Metformin to Reduce Frailty in Older Adults with Glucose Intolerance

Preprint: randomized trial in 145 peopleMetformin

Paper

NatureAug 20

Lab-grown human brain models recorded developmental time

Human brain organoids grown for five years showed cell-type-specific changes in gene activity and DNA-based age estimates that tracked time in culture.Human brain organoids grown for five years showed cell-type-specific changes in gene activity and DNA-based age estimates that tracked time in culture.