Elevated TyG combined with reduced NCCR

1. Elevated TyG combined with reduced NCCR is associated with cardiovascular-kidney-metabolic syndrome progression to stage 4 in humans.

   “the combination of elevated TyG and reduced NCCR, reflecting a “metabolic‐structural uncoupling” phenotype, was significantly correlated with heightened risk of CKM progression.”

   HumansJoint exposure analysis

   Combined blood marker linked to cardiovascular disease risk

   Cardiovascular diabetology·9 Oct 2026

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