Electronegative HDL subfraction H5
Biomarker1 paper3 findings
- Humans1
Effects
1Cellular senescence
upin animals1
1 study
Cellular senescence
upin animals1
Electronegative HDL subfraction H5 induces cellular senescence.
Animalsin vitro and in vivo
Apolipoprotein(a)-rich electronegative HDL accelerates vascular aging and atherosclerosis by inducing endothelial senescence · GeroScience · 9 Sep 2026
Upstream
1Metabolic syndrome
upin humans1
1 study
Metabolic syndrome
upin humans1
Metabolic syndrome increases electronegative HDL subfraction H5 in humans (4.0 ± 3.5% vs. 2.7 ± 1.0%).
Humansindividuals with cardiovascular disease risk vs controlsn = 131
Apolipoprotein(a)-rich electronegative HDL accelerates vascular aging and atherosclerosis by inducing endothelial senescence · GeroScience · 9 Sep 2026
Associations
1Intima-media thickness
upin humans1
1 study
Intima-media thickness
upin humans1
Electronegative HDL subfraction H5 is associated with intima-media thickness in humans.
Humansimaging cohortn = 118
Apolipoprotein(a)-rich electronegative HDL accelerates vascular aging and atherosclerosis by inducing endothelial senescence · GeroScience · 9 Sep 2026