Elastin fragmentation

Papers on elastin fragmentation

18 papers1 new in 30 days

Sunday, October 4

Acta BiomaterialiaOct 4

Human aortic elastin degrades with age in males but not females

In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.In 17 human thoracic aorta samples, elastin stiffness, straightness, and lamellar length decreased significantly with age in males (p < 0.05) but not females.

Cross-sectional study of 17 peopleMechanisms

Wednesday, July 8

PNASJul 8

Inhibition of elastin degradation alleviates joint degeneration in aging mice, dogs, and human models

Experiments in miceBones and joints

Mechanisms of Ageing and DevelopmentJul 8

Circulating elastin fragments drive systemic aging: Where do pro-aging elastin fragments come from? A mini-review

ReviewMechanisms

Tuesday, September 30

Nature AgingSep 30

Elastin-derived extracellular matrix fragments drive aging through innate immune activation

Study of 1,068 peopleImmune response

Tuesday, April 2

HypertensionApr 2

MFAP4-Deficiency Aggravates Age-Induced Changes in Resistance Artery Structure, While Ameliorating Hypertension

Experiments in miceMechanisms

Thursday, March 7

Aging CellMar 7

Ercc1 DNA repair deficiency results in vascular aging characterized by VSMC phenotype switching, ECM remodeling, and an increased stress response

Experiments in miceDNA repair

Friday, August 25

Vascular PharmacologyAug 25

Empagliflozin decreases ageing-associated arterial stiffening and vascular fibrosis under normoglycemic conditions

Experiments in miceEmpagliflozin

Sunday, May 14

Frontiers in PhysiologyMay 14

Elastin haploinsufficiency accelerates age-related structural and functional changes in the renal microvasculature and impairment of renal hemodynamics in female mice

Experiments in miceKidney

Sunday, August 14

Experimental GerontologyAug 14

Association between arterial stiffness and walking capacity in older adults

Cross-sectional study of 910 peopleBiomarkers

Saturday, August 13

Annals of Cardiothoracic SurgeryAug 13

Elastin integrity in bicuspid valve-associated aortopathy is associated with altered biomechanical properties and influenced by age

Cohort study of 19 peopleMechanisms

Tuesday, March 1

Frontiers in EndocrinologyMar 1

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases

ReviewMechanisms

Tuesday, November 16

PhysiologyNov 16

Is It Good to Have a Stiff Aorta with Aging? Causes and Consequences

ReviewMechanisms

Tuesday, August 10

Frontiers in Cell and Developmental BiologyAug 10

Statins Mitigate Stress-Related Vascular Aging and Atherosclerosis in apoE-Deficient Mice Fed High Fat-Diet: The Role of Glucagon-Like Peptide-1/Adiponectin Axis

Experiments in miceStatins

Friday, June 26

Current Gerontology and Geriatrics ResearchJun 26

Carotid Disease and Ageing: A Literature Review on the Pathogenesis of Vascular Senescence in Older Subjects

ReviewMechanisms

Friday, August 3

Journal of Vascular ResearchAug 3

Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging

ReviewMechanisms

Sunday, May 28

International Journal of CardiologyMay 28

Increased dipeptidyl peptidase-4 accelerates diet-related vascular aging and atherosclerosis in ApoE-deficient mice under chronic stress

Experiments in miceAtherosclerosis

Wednesday, September 14

HypertensionSep 14

Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity

Experiments in miceSirtuin signaling

Friday, March 25

Cardiovascular ResearchMar 25

Matrix ageing and vascular impacts: focus on elastin fragmentation

ReviewMechanisms