Effector CD8+ T cells

Papers on effector CD8+ T cells

29 papers1 new in 30 days

Monday, November 2

Research SquareNov 2

Senescence-associated KRAS upregulation in peripheral T cells links to premature coronary artery disease

Workflow of this study.

Preprint: cross-sectional study of 21 peopleCellular senescence

Monday, October 5

bioRxivOct 5

Nicotinamide riboside improves parasite control in mice

In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle.In mice infected with Trypanosoma cruzi, treatment with the NAD+ precursor improved CD8+ T-cell function and reduced parasite burden in blood and skeletal muscle.

T. cruzi infection induces glycolytic reprogramming in parasite-specific CD8⁺ T cells.

Preprint: experiments in miceNicotinamide riboside

Tuesday, September 29

bioRxivSep 29

T cell KRAS upregulation is linked to premature coronary disease

Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.Profiling blood and plaque samples from 12 patients and 21 controls linked elevated KRAS in senescent CD8+ T cells to premature coronary artery disease.

Workflow of this study.

Preprint: case-control study of 21 peopleKRAS

Friday, December 5

LifeDec 5

Ubiquitous Expression of mPolgmut Leads to the Accumulation of Cytotoxic CD8+ T Lymphocytes in Young Mice

Experiments in miceMechanisms

Wednesday, May 21

Aging CellMay 21

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8⁺ T Cells Responding to Coronavirus Infection

Experiments in miceStem cell differentiation

Monday, March 3

Frontiers in ImmunologyMar 3

Cytotoxic KLRG1+ IL-7R- effector CD8+ T cells distinguish kidney transplant recipients controlling cytomegalovirus reactivation

Cohort study of 62 peopleKidney

Friday, February 7

Frontiers in AgingFeb 7

Markers of immunosenescence in CMV seropositive healthy elderly adults

Cross-sectional study in peopleMechanisms

Saturday, December 28

Scientific ReportsDec 28

SLAMF7 defines subsets of human effector CD8 T cells

Study in peopleBlood and immune system

Tuesday, July 16

ImmunologyJul 16

Roles of Menin in T cell differentiation and function: Current knowledge and perspectives

ReviewBlood and immune system

Monday, July 1

bioRxivJul 1

antiCD49d Ab treatment ameliorates age-associated inflammatory response and mitigates CD8+ T-cell cytotoxicity after traumatic brain injury

Preprint: experiments in miceTraumatic brain injury

Sunday, August 13

Immunity & AgeingAug 13

Systemic immune response in young and elderly patients after traumatic brain injury

Case-control study in peopleImmune response

Monday, May 15

Cancer ScienceMay 15

Senescent CD8⁺ T cells acquire NK cell-like innate functions to promote antitumor immunity

Experiments in miceCellular senescence

Sunday, January 22

VaccinesJan 22

Ageing Curtails the Diversity and Functionality of Nascent CD8⁺ T Cell Responses against SARS-CoV-2

Study in peopleImmune response

Monday, July 25

bioRxivJul 25

Multi-omics integrated analysis reveals a specific phenotype of CD8+ T cell may contribute to immunothromosis via Th17 response in severe and critical COVID-19

Preprint: computational studyImmune response

Wednesday, July 13

Advanced ScienceJul 13

Genetic Disruption of KLF1 K74 SUMOylation in Hematopoietic System Promotes Healthy Longevity in Mice

Experiments in miceBlood and immune system

Tuesday, February 15

iScienceFeb 15

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling

Experiments in animalsNicotinamide

Friday, November 12

Research SquareNov 12

Poly-γ-Glutamic Acid/Alum Adjuvanted pH1N1 Vaccine-Immunized Aged Mice Exhibit a Significant Increase In Vaccine Efficacy With a Decrease in Age-Associated CD8+ T Cell Proportion in Splenocytes

Preprint: experiments in miceBlood and immune system

Saturday, October 30

Frontiers in ImmunologyOct 30

Better Response to Influenza Virus Vaccination in Physically Trained Older Adults Is Associated With Reductions of Cytomegalovirus-Specific Immunoglobulins as Well as Improvements in the Inflammatory and CD8⁺ T-Cell Profiles

Study of 80 peopleBlood and immune system

Friday, July 30

Frontiers in ImmunologyJul 30

A Single-Cell Atlas of Lymphocyte Adaptive Immune Repertoires and Transcriptomes Reveals Age-Related Differences in Convalescent COVID-19 Patients

Cohort study in peopleImmune response

Sunday, September 20

mBioSep 20

Impaired Cytotoxic CD8⁺ T Cell Response in Elderly COVID-19 Patients

Study in peopleMechanisms

Thursday, November 7

AIDSNov 7

The proportion of CD57+ cells among effector CD8+ T cells is lower in HIV controllers compared with antiretroviral therapy-treated patients

Study in peopleMechanisms

Friday, October 18

Frontiers in ImmunologyOct 18

Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18

Experiments in miceBlood and immune system

Monday, November 13

Experimental GerontologyNov 13

Strain specificities in age-related changes in mechanisms promoting and controlling rat spinal cord damage in experimental autoimmune encephalomyelitis

Experiments in ratsMechanisms

Saturday, August 26

The Journal of Infectious DiseasesAug 26

Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents

Cohort study of 187 peopleImmune response

Wednesday, July 5

Frontiers in ImmunologyJul 5

Increased IL-15 Production and Accumulation of Highly Differentiated CD8⁺ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus

Cross-sectional study in peopleBlood and immune system

Saturday, July 1

Frontiers in ImmunologyJul 1

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging

Study in peopleImmune response

Wednesday, October 26

OncotargetOct 26

IL-2 and IL-6 cooperate to enhance the generation of influenza-specific CD8 T cells responding to live influenza virus in aged mice and humans

Study in peopleInfluenza

Thursday, April 28

OncotargetApr 28

Inflammatory and immune markers associated with physical frailty syndrome: findings from Singapore longitudinal aging studies

Cross-sectional study in peopleBiomarkers

Monday, March 2

Microbial CellMar 2

New roles for autophagy and spermidine in T cells

CommentaryAutophagy