Doublecortin-positive cells

Biomarker

3 papers study it2 findings

  • Animals3

Interventions

2

Alpha-glycerophosphocholine

upin mice1

1 study
  1. Alpha-glycerophosphocholine increases doublecortin-positive cells in mice.

    “The GPC intake suppressed microglial activation and BBB disruption and sustained doublecortin-positive cells in the hippocampus.”

    Animalsin SAMP8 micehippocampus

    Long-term intake of α-glycerophosphocholine (GPC) suppresses microglial inflammation and blood-brain barrier (BBB) disruption and promotes neurogenesis in senescence-accelerated mice prone 8 (SAMP8)

    Bioscience, biotechnology, and biochemistry

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Caloric restriction

no changein mice1

1 study
  1. Caloric restriction has no effect on doublecortin-positive cells in mice.

    “however, this increased proliferative activity of stem and progenitor cells did not result in a significant increase in the number of doublecortin-positive newborn neurons.”

    Animalsdentate gyrusfemales

    Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain

    The European journal of neuroscience

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