DNA methylation scores

There are 2 papers on DNA methylation scores in aging research: 2 observational studies in people. The newest story, Oct 28, 2026: “Combined biological scores link to heart risks across ancestries”.

Biomarker

2 papers study it8 more mention it1 finding

2 new papers in 30 daysSee all 10 papers on DNA methylation scores

“we show that the use of blood-based DNA methylation information leads to a significant improvement in the prediction of 10-year T2D incidence risk”
Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetesNature aging2023doi:10.1038/s43587-023-00391-4
  • Humans2

Associations

1

Type 2 diabetes

upin humans1

1 study
  1. DNA methylation scores predict type 2 diabetes in humans (AUC = 0.872 vs 0.839).

    “we show that the use of blood-based DNA methylation information leads to a significant improvement in the prediction of 10-year T2D incidence risk”

    Humans10-year

    Development and validation of DNA methylation scores in two European cohorts augment 10-year risk prediction of type 2 diabetes

    Nature aging

More on Type 2 diabetes

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 1Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 1Sep 2026: 1Oct 2026: 2Nov 2026: 05 papers in 12 months
medRxiv

Combined biological scores link to heart risks across ancestries

For cardiovascular death, a measure of how well scores separated cases from noncases was 0.83 for the combined score versus 0.78 for a clinical model.For cardiovascular death, a measure of how well scores separated cases from noncases was 0.83 for the combined score versus 0.78 for a clinical model.

Preprint: cohort studyBiomarkers
Genes

Blood methylation clocks capture two distinct biological domains of aging

Specific epigenetic measures track mitotic cell replication, while others capture systemic dysregulation driven by inflammation, metabolic factors, and lifestyle…Specific epigenetic measures track mitotic cell replication, while others capture systemic dysregulation driven by inflammation, metabolic factors, and lifestyle exposures.

Cohort study in peopleBiomarkers