What does the research say about megascore-CV-Death?

Megascore-CV-Death

There is 1 paper on megascore-CV-Death in aging research: 1 observational study in people. The newest story, Oct 28, 2026: “Combined biological scores link to heart risks across ancestries”.

Biomarker

1 paper studies it2 findings

1 new paper in 30 daysSee all 1 papers on megascore-CV-Death

“cardiovascular mortality (HR, 3.28; 95% CI, 2.33-4.61)”

Integrated multiomic scores for cardiovascular disease prediction across multiancestral populationsmedRxiv2026doi:10.64898/2026.10.23.26366372

Humans1

Effects

Cardiovascular mortality discrimination

upin humans1

1 study

Megascore-CV-Death is linked with better cardiovascular mortality discrimination in humans (Compared with SCORE2) (AUC 0.83 (95% CI 0.82–0.85) versus 0.78 (95% CI 0.77–0.80)).
“MEGASCORE-CV-Death had a higher area under the receiver operating characteristic curve (AUC) than SCORE2 for cardiovascular mortality”
HumansCompared with SCORE2
Combined biological scores link to heart risks across ancestries
medRxivOct 28, 2026Preprint

Associations

Cardiovascular mortality

upin humans1HR 3.28

1 study

Megascore-CV-Death is associated with cardiovascular mortality in humans (Pooled analyses; per standard deviation increase in the corresponding MEGASCORE) (HR 3.28, 95% CI 2.33–4.61 per standard deviation).
“cardiovascular mortality (HR, 3.28; 95% CI, 2.33-4.61)”
HumansPooled analyses; per standard deviation increase in the corresponding MEGASCORE
Combined biological scores link to heart risks across ancestries
medRxivOct 28, 2026Preprint

Latest

1 paper in 12 months

medRxivOct 28

Combined biological scores link to heart risks across ancestries

For cardiovascular death, a measure of how well scores separated cases from noncases was 0.83 for the combined score versus 0.78 for a clinical model.For cardiovascular death, a measure of how well scores separated cases from noncases was 0.83 for the combined score versus 0.78 for a clinical model.

Preprint: cohort studyBiomarkers

Paper