DNA methylation age acceleration

1. DNA methylation age acceleration has no effect on longitudinal change in cognitive performance in humans.

   “neither age acceleration nor chronological age were predictive of differences in longitudinal change.”

   Humanssymbol search and n-back tasks across four annual burstsfour annual burstsn = 142

   EXPLORING EPIGENETIC CLOCKS AND COGNITIVE CHANGE IN MIDDLE ADULTHOOD

   GSA 2024 abstract·31 Dec 2024

1. Early-onset colorectal cancer is associated with DNA methylation age acceleration in humans (12 years compared with average-onset colorectal cancer).

   “We found that DNA methylation (DNAm) age acceleration by12 years when compared with average-onset CRC (AOCRC) patients.”

   HumansEarly-onset versus average-onset colorectal cancer

   Epigenetic Modulation, Intra-tumoral Microbiome and Immunity in Early Onset Colorectal Cancer

   bioRxiv : the preprint server for biology·2 Apr 2025Preprint

More on Early-onset colorectal cancer

1. DNA methylation age acceleration is associated with cognitive score fluctuations in humans.

   “greater age acceleration (but not chronological age) was associated with more fluctuations in scores across the study period”

   Humansacross four annual bursts of datafour annual burstsn = 142

   EXPLORING EPIGENETIC CLOCKS AND COGNITIVE CHANGE IN MIDDLE ADULTHOOD

   GSA 2024 abstract·31 Dec 2024

1. DNA methylation age acceleration is associated with peak cognitive performance in humans.

   “for both tasks we found that peak performance (at burst 1) was slower for individuals with greater age acceleration”

   Humansprocessing speed and working memory tasks across midlife adultsfour annual burstsn = 142

   EXPLORING EPIGENETIC CLOCKS AND COGNITIVE CHANGE IN MIDDLE ADULTHOOD

   GSA 2024 abstract·31 Dec 2024