4 papers6 findings
Parenting experience
upin A. nancymaae1
Parenting experience increases DNA hypomethylation in A. nancymaae.
“Parenting experience also accelerated DNA methylation loss with age, but this effect was specific to the brain”
Animalsbrain
Global DNA Hypomethylation as a Biomarker of Accelerated Epigenetic Ageing in Primates
bioRxiv (Cold Spring Harbor Laboratory)30 Mar 2024Preprint
Maternal rejection
upin A. nancymaae1
Maternal rejection increases DNA hypomethylation in A. nancymaae.
“this age-related blood hypomethylation in individuals experiencing early life maternal rejection was accelerated”
Animalsearly life maternal rejectionblood
Global DNA Hypomethylation as a Biomarker of Accelerated Epigenetic Ageing in Primates
bioRxiv (Cold Spring Harbor Laboratory)30 Mar 2024Preprint
DNA G-quadruplexes
upin human cells1
DNA G-quadruplexes increase DNA hypomethylation in human cells.
“G4s gradually accumulate on promoters throughout mitosis, driving clock-like DNA hypomethylation and chromatin opening.”
Cells
A universal molecular mechanism driving aging
bioRxiv (Cold Spring Harbor Laboratory)6 Jan 2024Preprint
Retrotransposon expression
upin humans3
DNA hypomethylation is associated with retrotransposon expression in humans.
“the significant increase in RTE expression level in hypomethylated RTEs except for SINEs.”
HumansHypomethylated retrotransposons, excluding short interspersed nuclear elementsblood
Expression of most retrotransposons in human blood correlates with biological aging
eLife17 Oct 2024
DNA hypomethylation is associated with retrotransposon expression in humans.
“significant increase in RTE expression level in hypomethylated RTEs except for SINEs.”
HumansHypomethylated retrotransposons, except SINEsblood
Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging
eLife3 Oct 2024Preprint
DNA hypomethylation is associated with retrotransposon expression in humans.
“DNA hypomethylation with aging was observed across RTE classes and associated with increased RTEs expression in most RTE classes and families except SINEs.”
HumansMost retrotransposon classes and families, except SINEsblood
Expression of Most Retrotransposons in Human Blood Correlates with Biological Aging
eLife1 May 2024Preprint
Using human stem cell-derived macrophages, a preprint finds DNMT3A mutations derepress bivalent Polycomb target genes and enhance cell migration toward injured tissue.Using human stem cell-derived macrophages, a preprint finds DNMT3A mutations derepress bivalent Polycomb target genes and enhance cell migration toward injured tissue.