Discrimination
Biomarker1 paper1 finding
- Humans1
Upstream
1LG.CVDRisk
upin humans1
1 study
LG.CVDRisk
upin humans1
LG.CVDRisk improves discrimination in humans (ΔC 0.071, 95% CI 0.033-0.109).
Humansamong intermediate-risk individualsn = 13,521
Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study · EClinicalMedicine · 24 Aug 2026
Latest
793Detailed ability checks added little to ranking death risk
After accounting for demographic and social factors and multiple illnesses, death-risk ranking scores were 0.723 for brief screening, 0.731 for…After accounting for demographic and social factors and multiple illnesses, death-risk ranking scores were 0.723 for brief screening, 0.731 for comprehensive assessment and 0.736 for statistical scoring.
Three-region brain aging model better predicted death risk
A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.A three-region model scored 0.81 versus 0.79 for a whole-brain model on a measure of how well it ranked death risk.
Explainable AI reveals biological heterogeneity associated with algorithmic failure in ovarian cancer screening
Treadmill fitness improved ten-year death risk predictions
A model’s score for distinguishing higher from lower death risk rose from 0.662 using traditional risk factors alone to 0.682 after adding treadmill…A model’s score for distinguishing higher from lower death risk rose from 0.662 using traditional risk factors alone to 0.682 after adding treadmill fitness.
Higher glucose disposal rate linked to lower multimorbidity risk
In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple…In two prospective cohorts, each standard deviation increase in estimated glucose disposal rate was associated with a 40% lower risk of multiple cardiometabolic diseases.
Larger lung artery volume tied to deaths in smokers without COPD
Each roughly 25-millilitre increase in artery volume was linked to a death-rate ratio of 1.42 in one cohort and 1.23 in another.Each roughly 25-millilitre increase in artery volume was linked to a death-rate ratio of 1.42 in one cohort and 1.23 in another.
Incremental value of AI-derived retinal vascular parameters for predicting incident type 2 diabetes
Inherited gene variants linked to breast cancer risk in UAE
Women carrying variants classed as harmful or likely harmful made up 0.84% of women studied and 5.2% of breast cancer cases.Women carrying variants classed as harmful or likely harmful made up 0.84% of women studied and 5.2% of breast cancer cases.