Deubiquitylase catalytic activity

1. N-acetylcysteine ethyl ester increases deubiquitylase catalytic activity.

   “antioxidant treatment with N-acetylcysteine ethyl ester (NACET) restored activity in aging brains.”

   Animalsbrain

   Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

   Nature communications·21 Apr 2026

More on N-acetylcysteine ethyl ester

1. Age is associated with deubiquitylase catalytic activity in killifish.

   “We identified a subset of DUBs that progressively lose catalytic activity with age despite stable protein abundance.”

   Animalsbrain

   Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

   Nature communications·21 Apr 2026

2. Age is associated with deubiquitylase catalytic activity in mice.

   “We identified a subset of DUBs that progressively lose catalytic activity with age despite stable protein abundance.”

   Animalsbrain

   Oxidative stress causes a reversible decrease of deubiquitylases activity in old vertebrate brains

   Nature communications·21 Apr 2026