Dentate gyrus volume

1. BDNFMETALLELE is linked with higher dentate gyrus volume in humans (anterior hippocampus (head); Met-carriers compared with Val/Val homozygotes).

   “BDNF polymorphism was associated with larger dentate gyrus volumes within the anterior hippocampus (head) in Met-carriers compared to Val/Val homozygotes.”

   Humansanterior hippocampus (head); Met-carriers compared with Val/Val homozygotesanterior hippocampusn = 127

   The associations of the BDNF and APOE polymorphisms, hippocampal subfield volumes, and episodic memory performance across the lifespan

   Hippocampus·Jun 23, 2020

More on BDNFMETALLELE

1. Dentate gyrus volume is associated with global cognitive function in humans (healthy older adults) (estimate -0.57; 95% CI -0.94 - -0.19; p = 0.003).

   “Decline in multiple hippocampal subfields was associated with global cognitive decline”

   Humanshealthy older adultshippocampus4-year periodn = 482

   Relationship between hippocampal subfield volumes and cognitive decline in healthy subjects

   Frontiers in aging neuroscience·Dec 7, 2023

1. Dentate gyrus volume predicts visuospatial memory performance in humans.

   “the volume of the dentate gyrus subfield and posterior hippocampus (body) showed a significant direct effect on visuospatial memory performance”

   Humansn = 126

   Contributions of hippocampal subfields and subregions to episodic memory performance in healthy cognitive aging

   Neurobiology of aging·Oct 20, 2023

1. Dentate gyrus volume is associated with memory performance in SMC(+) participants.

   “Regression analyses further showed significant associations between lower volume of the dentate gyrus and both poorer memory performance and higher plasma Aβ1-42 levels in SMC(+) participants.”

   Humansin SMC(+) participants

   Regional Hippocampal Atrophy and Higher Levels of Plasma Amyloid-Beta Are Associated With Subjective Memory Complaints in Nondemented Elderly Subjects

   The journals of gerontology. Series A, Biological sciences and medical sciences·Mar 4, 2016