DDIT4 expression

1. CBX8 decreases DDIT4 expression in cells.

   “CBX8 achieves this by recruiting TRIM28 to bind the promoter region of DDIT4, thereby maintaining the H3K27me3 modification status and repressing expression of DDIT4.”

   CellsThrough TRIM28 recruitment and maintenance of H3K27me3colorectal cancer cell

   CBX8 suppresses autophagy-dependent senescence in colorectal cancer by modulating the mTOR signaling pathway

   International journal of biological sciences·26 Feb 2026

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