Redox Biology·Nov 11A role for the cystathionine-β-synthase /H₂S axis in astrocyte dysfunction in the aging brainExperiments in human cellsMechanismsPaper
bioRxiv·Nov 8Protein thiol alterations drive aberrant phase separation in agingPreprint: experiments in miceMechanismsPaper
Journal of Agricultural and Food Chemistry·Nov 1Depletion of L-Methionine in Foods with an Engineered Thermophilic Methionine γ-lyase Efficiently Inhibits Tumor GrowthExperiments in miceInterventionsPaper
Circulation Research·Oct 6Disrupted Binding of Cystathionine γ-Lyase to p53 Promotes Endothelial SenescenceExperiments in human cellsCellular senescencePaper
Aging·Jun 23Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndromeExperiments in miceInterventionsPaper
GeroScience·May 23Cystine rather than cysteine is the preferred substrate for β-elimination by cystathionine γ-lyase: implications for dietary methionine restrictionExperiments in animalsDietary restrictionPaper
Biogerontology·Jan 21Simultaneous activation of the hydrogen sulfide biosynthesis genes (CBS and CSE) induces sex-specific geroprotective effects in Drosophila melanogasterExperiments in fliesInterventionsPaper
Redox Biology·Jan 7Effects of methionine intake on cognitive function in mild cognitive impairment patients and APP/PS1 Alzheimer's Disease model mice: Role of the cystathionine-β-synthase/H₂S pathwayExperiments in miceMild cognitive impairmentPaper
European Journal of Nutrition·Dec 21The acute postprandial response of homocysteine to multivitamin and mineral supplementation with a standard meal is not impaired in older compared to younger adultsNon-randomized trial in peopleInterventionsPaper
Alzheimer's & Dementia·Dec 15Genetic expression changes and pathologic findings associated with hyperhomocysteinemia in human autopsy brain tissueStudy in peopleMechanismsPaper
Biochimica et Biophysica Acta Molecular Cell Research·Nov 14H₂S contributed from CSE during cellular senescence suppresses inflammation and nitrosative stressExperiments in cellsCellular senescencePaper
bioRxiv·Sep 5A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprogramingPreprint: experiments in human cellsInterventionsPaper
Experimental Aging Research·Jul 19Aerobic Training with Naringin Supplementation Improved Spatial Cognition via H₂S Signaling Pathway in Alzheimer's Disease Model RatsExperiments in ratsInterventionsPaper
Nutrients·Jun 25The Association of Circulating Amino Acids and Dietary Inflammatory Potential with Muscle Health in Chinese Community-Dwelling Older PeopleCohort study of 2,994 peopleMusclePaper
FASEB Journal·Mar 23Homozygous whole body Cbs knockout in adult mice features minimal pathology during ageing despite severe homocysteinemiaExperiments in miceMechanismsPaper
Mechanisms of Ageing and Development·Mar 6Deletions of the cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) genes, involved in the control of hydrogen sulfide biosynthesis, significantly affect lifespan and fitness components of Drosophila melanogasterExperiments in fliesMechanismsPaper
Molecular and Cellular Biochemistry·Feb 12H₂S protects from oxidative stress-driven ACE2 expression and cardiac agingExperiments in miceOxidative stress and ROS signalingPaper
Experimental Eye Research·Dec 16Effect of long-term chronic hyperhomocysteinemia on retinal structure and function in the cystathionine-β-synthase mutant mouseExperiments in animalsMechanismsPaper
The Journal of Nutrition·Oct 14Assessment of Dietary Choline Intake, Contributing Food Items, and Associations with One-Carbon and Lipid Metabolites in Middle-Aged and Elderly Adults: The Hordaland Health StudyCross-sectional study of 5,746 peoplePopulationsPaper
European Journal of Clinical Investigation·Sep 30Pyridoxal-5-phosphate induced cardioprotection in aging associated with up-expression of cystathionine-γ-lyase, 3-mercaptopyruvate sulfurtransferase, and ATP-sensitive potassium channelsExperiments in ratsInterventionsPaper
Molecules·Sep 29Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon MetabolismExperiments in chickensInterventionsPaper
Frontiers in Pharmacology·Sep 17Hydrogen Sulfide Prevents Mesenteric Adipose Tissue Damage, Endothelial Dysfunction, and Redox Imbalance From High Fructose Diet-Induced Injury in Aged RatsExperiments in ratsEndothelial dysfunctionPaper
Communications Biology·Jun 13Plasma methionine metabolic profile is associated with longevity in mammalsExperiments in animalsMethionine and one-carbon metabolismPaper
Cells·Jun 3Hypertension and Aging Affect Liver Sulfur Metabolism in RatsExperiments in animalsMechanismsPaper
FASEB Journal·Apr 8Cystathionine gamma-lyase/H₂ S signaling facilitates myogenesis under aging and injury conditionExperiments in miceMechanismsPaper
Antioxidants & Redox Signaling·Mar 20Gasping for Sulfide: A Critical Appraisal of Hydrogen Sulfide in Lung Disease and Accelerated AgingReviewInterventionsPaper
Nature Communications·Mar 19Dietary restriction transforms the mammalian protein persulfidome in a tissue-specific and cystathionine γ-lyase-dependent mannerExperiments in miceDietary restrictionPaper
Biomedicines·Feb 13Effect of Methionine Restriction on Aging: Its Relationship to Oxidative StressReviewDietary restrictionPaper
Biogerontology·Feb 6Geroprotective potential of genetic and pharmacological interventions to endogenous hydrogen sulfide synthesis in Drosophila melanogasterExperiments in fliesInterventionsPaper
GeroScience·Jan 13Exogenous hydrogen sulfide and miR-21 antagonism attenuates macrophage-mediated inflammation in ischemia reperfusion injury of the aged kidneyExperiments in miceKidneyPaper