CTSB expression

Biomarker

1 paper1 finding

Humans1

Associations

White matter hyperintensities

downin humans1

1 study

White matter hyperintensities are associated with CTSB expression in humans (log2 fold change: -1.70 in astrocytes; -0.48 in oligodendrocytes).
“Single-nucleus RNA sequencing showed CTSB downregulation within lesions, predominantly in astrocytes (log2 fold change=-1.70) and oligodendrocytes (log2 fold change=-0.48; both false discovery rate P<1×10−20).”
HumansWMH lesions compared with controlsperiventricular white matter50% femalesn = 8
Blood protein linked to lower brain lesion volume
Stroke16 Oct 2026

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Blood protein linked to lower brain lesion volume

Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.

Cohort study of 5,260 UK Biobank participantsMechanisms

Limit: The postmortem comparison supporting lesion-related cathepsin B changes involved only eight samples

Paper

European Archives of Psychiatry and Clinical Neuroscience5 Jan

Cell senescence-related pathogenic genes in sleep disorders: a multi-omics Mendelian randomization study

Mendelian randomisation in peopleCellular senescence