WMH polygenic risk score

Biomarker

1 paper

  • Humans1

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Blood protein linked to lower brain lesion volume

Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.Higher blood levels of the protein cathepsin B were linked to lower lesion volume, with an association estimate of minus 0.09 in 5,260 people.

Cohort study of 5,260 UK Biobank participantsMechanisms

Limit: The postmortem comparison supporting lesion-related cathepsin B changes involved only eight samples