CTRP1+SGLT2+ double-positive tubular cells

1 paper1 finding

Humans1

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Dapagliflozin

downin rats1

1 study

Dapagliflozin decreases CTRP1+SGLT2+ double-positive tubular cells in rats.
“Dapagliflozin suppressed CTRP1-SGLT2 axis activation, reduced glucose uptake in renal tubular cells, and markedly decreased the proportion of CTRP1+SGLT2+ double-positive tubular cells.”
Animalsin HFD/STZ/UNx-induced DKD ratskidney0.1 mg/kg/day
SGLT2 Inhibition Attenuates Renal Tubular Senescence by Suppressing CTRP1-Mediated Glucotoxic Stress in Diabetic Kidney Disease
FASEB journal : official publication of the Federation of American Societies for Experimental Biology16 Jul 2026

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FASEB Journal16 Jul

SGLT2 Inhibition Attenuates Renal Tubular Senescence by Suppressing CTRP1-Mediated Glucotoxic Stress in Diabetic Kidney Disease

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