DIFFERENTIAL RESPONSES TO AGING AMONG THE TRANSCRIPTOME AND PROTEOME OF MESENCHYMAL PROGENITOR POPULATIONS

Abstract

Cellular senescence, a hallmark of aging, results in a senescence-associated secretory phenotype (SASP) with an increased production of proinflammatory cytokines, growth factors, and proteases. Evidence from nonhuman models demonstrates that SASP contributes to tissue dysfunction and pathological effects of aging.