CSF phosphorylated tau 181

1. Rapamycin increases CSF phosphorylated tau 181 in humans.

   “In contrast, participants in the therapeutic trial displayed increased plasma cytokines and CSF phosphorylated tau 181, neurofilament light, and glial fibrillary acidic protein levels (FDR-corrected p-value<0.05).”

   Human trialin older adults with mild cognitive impairment or dementiacerebrospinal fluid1 mg/day4-12 week

   Stage-Dependent Effects of Rapamycin for Alzheimer’s Disease: Insights from Prevention and Treatment Trials

   GSA 2025 abstract·31 Dec 2025

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