CSF brain-age acceleration

1. CSF brain-age acceleration predicts dementia conversion in humans.

   “and predictive of longitudinal cognitive decline, neuroimaging progression, and dementia conversion.”

   Humanslongitudinal follow-up

   A cerebrospinal fluid proteomic clock reveals opposing brain-aging programs and predicts neurological disease progression

   bioRxiv (Cold Spring Harbor Laboratory)·1 Jul 2026Preprint

1. CSF brain-age acceleration predicts cognitive function in humans.

   “and predictive of longitudinal cognitive decline, neuroimaging progression, and dementia conversion.”

   Humanslongitudinal follow-up

   A cerebrospinal fluid proteomic clock reveals opposing brain-aging programs and predicts neurological disease progression

   bioRxiv (Cold Spring Harbor Laboratory)·1 Jul 2026Preprint

1. CSF brain-age acceleration is associated with blood-brain barrier dysfunction in humans.

   “CSF brain-age acceleration was increased across diverse neurological diseases, associated with blood-brain barrier (BBB) dysfunction”

   Humansbrain

   A cerebrospinal fluid proteomic clock reveals opposing brain-aging programs and predicts neurological disease progression

   bioRxiv (Cold Spring Harbor Laboratory)·1 Jul 2026Preprint

1. Neurological disease is associated with CSF brain-age acceleration in humans.

   “CSF brain-age acceleration was increased across diverse neurological diseases”

   Humansdiverse neurological diseasescerebrospinal fluid

   A cerebrospinal fluid proteomic clock reveals opposing brain-aging programs and predicts neurological disease progression

   bioRxiv (Cold Spring Harbor Laboratory)·1 Jul 2026Preprint

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