Circulating SIRT1

1. Caloric restriction increases circulating SIRT1 in humans (p < 0.001).

   “Both interventions increased circulating SIRT1 (p < 0.001).”

   Human trial30 daysn = 48

   Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

   Nutrients·Jun 29, 2023

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1. Resveratrol increases circulating SIRT1 in humans (p < 0.001).

   “Both interventions increased circulating SIRT1 (p < 0.001).”

   Human trial30 daysn = 48

   Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

   Nutrients·Jun 29, 2023

More on Resveratrol

1. Bariatric surgery decreases circulating SIRT1 in humans (Baseline, 6 and 12 months: 156.8, 119.5 and 94.9 ng/mL, respectively).

   “SIRT1 concentration was significantly reduced from baseline to six and 12 months after surgery”

   Humansmorbid obesityplasma6 and 12 months80% womensn = 110

   Changes in circulating sirtuin 1 after bariatric surgery

   Nutrition, metabolism, and cardiovascular diseases : NMCD·Sep 22, 2022

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1. Circulating SIRT1 is associated with nitrate-mediated vasodilation in humans (r = 0.433, p < 0.01).

   “post-treatment circulating SIRT1 was correlated with NMD (r = 0.433; p < 0.01).”

   Human trial

   Sirtuin 1 and Vascular Function in Healthy Women and Men: A Randomized Clinical Trial Comparing the Effects of Energy Restriction and Resveratrol

   Nutrients·Jun 29, 2023

1. Triglyceride predicts circulating SIRT1 in humans.

   “CRP and triglycerides were both positively predictive of SIRT1 levels (p ≤ 0.001, both).”

   Humansmorbid obesity undergoing bariatric surgery80% womensn = 110

   Changes in circulating sirtuin 1 after bariatric surgery

   Nutrition, metabolism, and cardiovascular diseases : NMCD·Sep 22, 2022

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1. C-reactive protein predicts circulating SIRT1 in humans.

   “CRP and triglycerides were both positively predictive of SIRT1 levels (p ≤ 0.001, both).”

   Humansmorbid obesity undergoing bariatric surgery80% womensn = 110

   Changes in circulating sirtuin 1 after bariatric surgery

   Nutrition, metabolism, and cardiovascular diseases : NMCD·Sep 22, 2022

More on C-reactive protein